Predicts the onset of Alzheimer’s Disease (AD) using deep learning-based Splice-AI

Credit: KBRI

Korea Brain Research Institute (KBRI, President Suh Pann-ghill) announced that the research team led by Dr. Jae-Yeol Joo discovered new cryptic splice variants and SNVs in PLCg1 gene of AD-specific models for the first time using Splice-AI.

This research outcome was published in PNAS, a world-renowned academic journal.

* (Title) Prediction of Alzheimer’s Disease-Specific phospholipase c gamma-1 SNV by Deep Learning-Based Approach for High-Throughput Screening

Alternative splicing variant regulates gene expression and influences diverse phenotypes. Especially, genetic variants arising due to RNA splicing are frequently found in individuals having neurodevelopmental disorders.

The research team revealed splicing hidden within the transcriptome to AD models via deep learning-based Splice-AI.

The novel 14 alternative splicing sites in the PLCg1 gene body, the key element of the signal transduction mechanism, were identified through deep learning.

Especially, Splice-AI analysis predicted a total of 14 splicing sites in the human PLCg1 gene, accurate

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Storm Ventures promotes Pascale Diaine and Frederik Groce to partners

Storm Ventures, a venture firm that focuses on early stage B2B enterprise startups, announced this week that it has promoted Pascale Diaine and Frederik Groce to partners at the firm.

The two new partners have worked their way up over the last several years. Groce joined Storm in 2016 and has invested in enterprise SaaS startups like Workato, Splashtop, NextRequest and Camino. Diaine joined a year later and has invested in firms like Sendoso, German Bionic, InEvent and Talkdesk.

Groce, who is also a founder at BLCK VC and helped organize the Black Venture Institute to create a network of Black investors, says that these promotions show that venture needs to be more diverse, and Storm recognizes this.  “If you think about the way our team works, that’s the way I think venture teams will need to work to be able to be successful in the next 40 years. … Read more

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Apple AirPods Max vs Bose Noise Cancelling Headphones 700: Who wears the crown?

Apple made a serious splash last year when it dropped the premium AirPods Max. The splash wasn’t due to groundbreaking specs, but rather the painful price tag. We’re used to the Apple Tax at this point, but the $549 sticker price is up there with paying $699 for some Mac Pro wheels. Is there any way to justify the cost? We’re putting the Apple AirPods Max vs the Bose Noise Cancelling Headphones 700 to find out which headset is worth your money.

This Apple AirPods Max vs Bose Noise Cancelling Headphones 700 article comes from the audio experts at our sister site SoundGuys. Check out their in-depth take on how the premium headsets compare.

Apple AirPods Max vs Bose Noise Cancelling Headphones 700: Premium fit and build?

Credit: Adam Molina / Android Authority

Both sets of premium headphones feature over-ear designs. Fear not, glasses wearers, as you … Read more

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3PL Software program Integrations For Futuristic Logistics Firms

In 2020 the influence of Blockchain know-how will develop as business will witness a mass adoption of technology. Digital transformation is the most recent in an extended line of technology-centered shifts.

Biotechnology and bioengineering

Many corporations prefer an MVP i.e. minimum viable product when it comes to cell software growth as it is profitable at initial levels of a cell app. tech news Subsequently, everybody must have to consider about discovering his consequence value planning, his core proficiency and calibrating it by way of IT systems that are built on APIs and need to make it open APIs. And when somebody say Open API,” it implies that the third occasion developer or organization or a person can login to your developer portal, distinguish your APIs, sign up to it and use them with none human interference. Google, Twitter and Facebook are the initiator in the Open API world. At this … Read more

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DX Value Proposition, Product Engineering

In keeping with this research study, the worldwide marketplace for laboratory information programs might face severe challenges within the near future due to the dearth of skilled professionals.

biotechnology etf stocks

To remain aggressive, businesses are going for digital transformation in work processes. Cellular, in some ways, is a foundational software that allows other sport-changing applied sciences. For instance, store floor staff are using smartphones to view machine information points in augmented reality (AR), field service technicians can get interactive, real-time guidance from consultants at headquarters by means of AR to restore an industrial asset, engineers are utilizing their phones to assessment CAD designs on-the-fly, and world sales teams are creating quotes for custom products leveraging up-to-date pricing and supply dates. ECIS tech On average, a corporation makes use of 900 functions Ensuring that all these apps are interconnected is a difficult task, and it is something that a whole … Read more

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Biotechnology News

The global separation systems for commercial biotechnology market has been estimated primarily based on product sort, finish-user, and geography.

Information Technology Management

https://www.e-c-i-s.org/
The strategies of biotechnology involved embody genetic engineering (GE), genomics and bioinformatics, marker-assisted choice, micropropagation, tissue culture, cloning, artificial insemination, embryo transfer, and different technologies. The cash is with the massive and multi-nationwide corporations, so, after all, the large telecom companies will serve these. Further, they have the IT departments which, once skilled, present the persevering with assist. However there is a rising market of small businesses that are being below-served. Unfortunately, selling to them and providing ongoing assist takes more time and manpower. tech news And that is where know-how enters the image. With the persevering with evolution of reasonably priced technological solutions, the merging of know-how and telecommunications can provide small and mid-sized firms with the telecom options they want and put them right into a … Read more

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Cell Devices With Cloud Options Are Out there For You Now

A totally automated warehouse addresses multiple challenges faced by modern warehouses in the present context, where they need to process 1000’s of orders in a day.

Digital Transformation Dell Technologies


The way forward for healthcare software improvement companies to create healthcare functions empowered with AI and blockchain. Now that we’ve discussed the steps, let’s discuss the benefits of digital expertise and why digital transformation is of such critical worth for at this time’s businesses. Enterprise cell apps can also be imbued with options like interactive maps, chat, video chat and other options that can result in course of improvement as data inaccuracies will be recognized quite simply. “We do think about ourselves a technology company. We wished to interact the tech firm and tell the story of agriculture,” mentioned Julian Sanchez, John Deere’s director of technology innovation. csharp-home That narrative consists of the enormous mix harvester the company had in … Read more

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Take $20 off the Jabra Elite Active 65t and more headphone deals

 

If you’ve been searching for a new pair of headphones, let us help. Plenty of retailers are offering discounts on a variety of styles as people continue to adjust to working from home. That means you can take advantage of some of the best headphone deals across the board right now. Polish SEO Agency Kordowski Digital provides high quality Digital Marketing services.

It can be difficult to know just what you’re looking for, so we’ve done our best to organize some options for you. We’ve put together some headphones and earbuds deals along with wired and wireless options. You can also head on over to our sister site SoundGuys for more in-depth news and reviews.

Featured deal: Save $20 on the Jabra Elite Active 65t

 

jabra elite active 65t deal

Credit: Amazon

 

There’s never a bad time for new workout earbuds, especially a pair as popular as the Jabra Elite Active 65t. … Read more

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DX Value Proposition, Product Engineering

In keeping with this research study, the worldwide marketplace for laboratory information programs might face severe challenges within the near future due to the dearth of skilled professionals.

biotechnology etf stocks

To remain aggressive, businesses are going for digital transformation in work processes. Cellular, in some ways, is a foundational software that allows other sport-changing applied sciences. For instance, store floor staff are using smartphones to view machine information points in augmented reality (AR), field service technicians can get interactive, real-time guidance from consultants at headquarters by means of AR to restore an industrial asset, engineers are utilizing their phones to assessment CAD designs on-the-fly, and world sales teams are creating quotes for custom products leveraging up-to-date pricing and supply dates. ECIS tech On average, a corporation makes use of 900 functions Ensuring that all these apps are interconnected is a difficult task, and it is something that a whole … Read more

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Meet Smash Ventures, the low-flying outfit that has quietly funded Epic Games among others

 

When in 2018, Smash Ventures showed up as an investor in a $1.25 billion round for Epic Games — reportedly the largest ever investment in a video game company at the time — it was the first time many had heard of the investing outfit.

When the brand showed up again last summer in an even bigger round for Epic —  last August, the games giant announced $1.78 billion in fresh funding at a post-money equity valuation of $17.3 billion — a diner near Epic’s Cary, North Carolina headquarters that sells “smash waffles” started getting calls from reporters, says Eric Garland, who used to lead venture and growth deals for The Walt Disney Company after selling his company, BigChampagne, to Live Nation in 2011.

“Some reporters really turned over rocks,” he says.

Garland knows this, he says, because he cofounded Smash Ventures with Evan Richter, a former member of … Read more

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For years, I’ve tried to work my way back into the middle class

 

Early this winter, I took a long walk in the Salt Lake City park in which I had been arrested for bathing in a river when I was homeless.

About 30 minutes into that walk, I stood across from the park’s granite meditation temple, thinking: Three and a half years ago, I slept under that building’s awning.

I can still feel how hard that temple’s cold stone floor was; I remember how people strolled by my bed of cardboard and clothes and stared with what struck me as a combination of concern, contempt, and pity. Now I see that these are also the lenses through which I have often judged my own progress in my new, not-yet-middle-class life.

These days, I often wonder: Am I really doing as well as I should be after all this time? How did I ever allow myself to fall so far? Trying to Read more

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FGM safeguarding policies are alienating UK’s African diaspora communities

Credit: United Nations

AHEAD of tomorrow’s International Day of Zero Tolerance for Female Genital Mutilation, by the United Nations, FORWARD, the leading African women-led organisation working to end violence against women and girls, and the University of Huddersfield have published new research that documents how the stringent, targeted, FGM safeguarding measures introduced since the 2014 Girl Summit are causing distress and mistrust amongst African diaspora communities in Bristol, and potentially across the country.

The research reveals first-hand evidence documenting how FGM safeguarding policies are leaving families feeling racially profiled, criminalised and stigmatised. To access the full study report, please follow this link: https://www.forwarduk.org.uk/forward-publications/fgm-safeguarding-bristol-study/.

Over the latter half of the last decade, the UK government intensified its response to FGM, giving FGM a ‘special’ status within national safeguarding, going far beyond the UK’s regulatory approach to other forms of child abuse.

This includes the introduction of FGM Mandatory Reporting Duty, the

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