Among the neurotransmitters in the brain, dopamine has gained an almost mythical status. Decades of research have established its contribution to several seemingly unrelated brain functions including learning, motivation, and movement, raising the question of how a single neurotransmitter can play so many different roles.
Untangling dopamine’s diverse functions has been challenging, in part because the advanced brain of humans and other mammals contain different kinds of dopamine neurons, all embedded in highly complex circuits. In a new study, Rockefeller’s Vanessa Ruta and her team dive deep into the question by looking instead at the
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