MERS DNA vaccine induces immunity, protects from virus challenge in preclinical model

Dose-sparing regimens and intradermal delivery have important implication for rapid clinical development of effective, well-tolerated and easy-to-distribute vaccines against MERS and other emerging coronaviruses.

Credit: The Wistar Institute

PHILADELPHIA — (April 22, 2021) — A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen. A similar vaccine candidate was previously shown to be safe and tolerable with a three-dose intramuscular injection regimen in a recently completed human phase 1 study and is currently in expanded studies of phase 1/2a trial.

New results were published today in JCI Insight.

“While several vaccine products are being advanced against MERS and other coronaviruses, low-dose delivery and shortened regimes are crucial to rapidly induce protective immunity, particularly during emerging outbreaks, as the current SARS-CoV-2 pandemic

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Lighting it up: Fast material manipulation through a laser

Credit: © Beaulieu

Making the speed of electronic technology as fast as possible is a central aim of contemporary materials research. The key components of fast computing technologies are transistors: switching devices that turn electrical currents on and off very quickly as basic steps of logic operations. In order to improve our knowledge about ideal transistor materials, physicists are constantly trying to determine new methods to accomplish such extremely fast switches. Researchers from the Fritz Haber Institute of the Max Planck Society in Berlin and the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg have now figured out that a novel type of ultrafast switch can be accomplished with light.

The physicists involved in the project are studying how to best get materials to change their properties – to make magnetic metals non-magnetic, for example, or to change the electric conductivity of a crystal. A material’s

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Hand surgeon performs first surgery with FDA-cleared wrist replacement implant he designed

Credit: Hospital for Special Surgery

Sixty-nine-year-old Mark Eisen says he waited seven years for a surgery he hopes will change his life. Last week, he had the first total wrist replacement with KinematX™, a new implant co-designed by Scott Wolfe, MD, chief emeritus of the Hand and Upper Extremity Service at Hospital for Special Surgery (HSS). Dr. Wolfe performed the surgery on April 15.

Severe arthritis in his right wrist caused ongoing pain and prevented Mr. Eisen, who lives in Atlanta, from engaging in activities he enjoys. He is right-handed, which makes it even more difficult. Seven years ago, he started to investigate treatments and learned about total wrist replacement surgery. But unlike knee and hip replacements, which are common and have excellent outcomes, wrist replacement surgery has not enjoyed the same degree of success.

Mr. Eisen’s online research prompted him to take his first trip to New York for

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Pandemic led to profound changes in multiple sclerosis clinical practice

UC Riverside-led national survey of MS specialists finds nearly 10% had been redeployed to the front lines of COVID-19 patient care

Credit: C. Rosema.

RIVERSIDE, Calif. — A survey of U.S. multiple sclerosis, or MS, specialist clinicians reveals the COVID-19 pandemic has created major changes in how they deliver care.

“Since the pandemic began, more than 95% of our survey respondents reported using telehealth platforms to provide care for their patients,” said Dr. Elizabeth Morrison-Banks, a health sciences clinical professor of neurology in the School of Medicine at the University of California, Riverside, who led the survey reported in the journal Multiple Sclerosis and Related Disorders. “Approximately one half of the respondents were MS specialist neurologists, four out of five of whom indicated that COVID-19 had changed how they were recommending and prescribing MS disease-modifying therapies.”

During the pandemic, the MS specialist neurologists tended to prescribe fewer immunosuppressive agents.

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USU researchers develop power converter for long-distance, underwater electric grids

Credit: Photo by Steve Johnson

News Release — Logan, UT — Apr. 16, 2021 — A team of researchers from Utah State University’s Power Electronics Lab have developed a DC current-to-DC voltage power converter. This converter is equipped for long distances and minimal maintenance, making it particularly useful in underwater power distribution networks.

Tarak Saha, a recent graduate of USU’s electrical engineering PhD program, designed the converter. Three other researchers, including recent PhD graduate Anindya Bagchi and electrical and computer engineering faculty Hongjie Wang and Regan Zane, added other operational aspects to Saha’s design and helped him build and test it. Their work was recognized with a patent in early March.

Scientists have been interested in building power networks on the ocean floor for years and for a number of reasons: ocean exploration, marine resource development, earthquake and tsunami monitoring etc. But because these networks often include a main power

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Cell Devices With Cloud Options Are Out there For You Now

A totally automated warehouse addresses multiple challenges faced by modern warehouses in the present context, where they need to process 1000’s of orders in a day.

Digital Transformation Dell Technologies


The way forward for healthcare software improvement companies to create healthcare functions empowered with AI and blockchain. Now that we’ve discussed the steps, let’s discuss the benefits of digital expertise and why digital transformation is of such critical worth for at this time’s businesses. Enterprise cell apps can also be imbued with options like interactive maps, chat, video chat and other options that can result in course of improvement as data inaccuracies will be recognized quite simply. “We do think about ourselves a technology company. We wished to interact the tech firm and tell the story of agriculture,” mentioned Julian Sanchez, John Deere’s director of technology innovation. csharp-home That narrative consists of the enormous mix harvester the company had in … Read more

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Take $20 off the Jabra Elite Active 65t and more headphone deals

 

If you’ve been searching for a new pair of headphones, let us help. Plenty of retailers are offering discounts on a variety of styles as people continue to adjust to working from home. That means you can take advantage of some of the best headphone deals across the board right now. Polish SEO Agency Kordowski Digital provides high quality Digital Marketing services.

It can be difficult to know just what you’re looking for, so we’ve done our best to organize some options for you. We’ve put together some headphones and earbuds deals along with wired and wireless options. You can also head on over to our sister site SoundGuys for more in-depth news and reviews.

Featured deal: Save $20 on the Jabra Elite Active 65t

 

jabra elite active 65t deal

Credit: Amazon

 

There’s never a bad time for new workout earbuds, especially a pair as popular as the Jabra Elite Active 65t. … Read more

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DX Value Proposition, Product Engineering

In keeping with this research study, the worldwide marketplace for laboratory information programs might face severe challenges within the near future due to the dearth of skilled professionals.

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To remain aggressive, businesses are going for digital transformation in work processes. Cellular, in some ways, is a foundational software that allows other sport-changing applied sciences. For instance, store floor staff are using smartphones to view machine information points in augmented reality (AR), field service technicians can get interactive, real-time guidance from consultants at headquarters by means of AR to restore an industrial asset, engineers are utilizing their phones to assessment CAD designs on-the-fly, and world sales teams are creating quotes for custom products leveraging up-to-date pricing and supply dates. ECIS tech On average, a corporation makes use of 900 functions Ensuring that all these apps are interconnected is a difficult task, and it is something that a whole … Read more

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Meet Smash Ventures, the low-flying outfit that has quietly funded Epic Games among others

 

When in 2018, Smash Ventures showed up as an investor in a $1.25 billion round for Epic Games — reportedly the largest ever investment in a video game company at the time — it was the first time many had heard of the investing outfit.

When the brand showed up again last summer in an even bigger round for Epic —  last August, the games giant announced $1.78 billion in fresh funding at a post-money equity valuation of $17.3 billion — a diner near Epic’s Cary, North Carolina headquarters that sells “smash waffles” started getting calls from reporters, says Eric Garland, who used to lead venture and growth deals for The Walt Disney Company after selling his company, BigChampagne, to Live Nation in 2011.

“Some reporters really turned over rocks,” he says.

Garland knows this, he says, because he cofounded Smash Ventures with Evan Richter, a former member of … Read more

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For years, I’ve tried to work my way back into the middle class

 

Early this winter, I took a long walk in the Salt Lake City park in which I had been arrested for bathing in a river when I was homeless.

About 30 minutes into that walk, I stood across from the park’s granite meditation temple, thinking: Three and a half years ago, I slept under that building’s awning.

I can still feel how hard that temple’s cold stone floor was; I remember how people strolled by my bed of cardboard and clothes and stared with what struck me as a combination of concern, contempt, and pity. Now I see that these are also the lenses through which I have often judged my own progress in my new, not-yet-middle-class life.

These days, I often wonder: Am I really doing as well as I should be after all this time? How did I ever allow myself to fall so far? Trying to Read more

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FGM safeguarding policies are alienating UK’s African diaspora communities

Credit: United Nations

AHEAD of tomorrow’s International Day of Zero Tolerance for Female Genital Mutilation, by the United Nations, FORWARD, the leading African women-led organisation working to end violence against women and girls, and the University of Huddersfield have published new research that documents how the stringent, targeted, FGM safeguarding measures introduced since the 2014 Girl Summit are causing distress and mistrust amongst African diaspora communities in Bristol, and potentially across the country.

The research reveals first-hand evidence documenting how FGM safeguarding policies are leaving families feeling racially profiled, criminalised and stigmatised. To access the full study report, please follow this link: https://www.forwarduk.org.uk/forward-publications/fgm-safeguarding-bristol-study/.

Over the latter half of the last decade, the UK government intensified its response to FGM, giving FGM a ‘special’ status within national safeguarding, going far beyond the UK’s regulatory approach to other forms of child abuse.

This includes the introduction of FGM Mandatory Reporting Duty, the

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Predictive policing is still racist—whatever data it uses

It’s no secret that predictive policing tools are racially biased. A number of studies have shown that racist feedback loops can arise if algorithms are trained on police data, such as arrests. But new research shows that training predictive tools in a way claimed to lessen bias has little effect.

Arrest data biases predictive tools because police are known to arrest more people in Black and other minority neighborhoods, which leads algorithms to direct more policing to those areas, which leads to more arrests. The result is that predictive tools misallocate police patrols: some neighborhoods are unfairly designated crime hotspots; others are underpoliced.

In their defence, many developers of predictive policing tools say that they have started using victim reports to get a more accurate picture of crime rates across different neighborhoods. In theory victim reports should be less biased because they aren’t affected by police prejudice or … Read more

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