Switch of breast tumors to HER2-low in recurrence may provide greater therapeutic options

ESMO Breast Cancer 2021 Virtual Congress, 5-8 May

Credit: ESMO

Lugano, Switzerland, 8 May 2021 – The finding that breast tumours can evolve to express low HER2 potentially widens the number of patients who can benefit from new investigational agents, typically novel antibody-drug conjugate therapies, that are currently in clinical trials for HER2-low tumours.

The first study of its kind exploring how breast cancers change from the primary to the recurrent tumour has revealed that nearly 30% of breast cancer patients convert from, or to, human epidermal growth factor receptor (HER)2-low status. Specifically, the study found that 14% of triple-negative breast cancers with HER2-negative expression (also referred to as HER2-0) in the primary tumour converted to HER2-low expression in the recurrent tumour possibly offering an option to such hard-to-treat tumours.

Traditionally, breast cancers are categorised as: hormone receptor positive (HR+)/HER 2-negative, (also known as luminal-like), HER2-positive, or triple negative (negative

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iPhone 12 Pro Max revisited: The good and bad six months later

The Apple iPhone 12 family is a bona fide success. Six of the top 10 smartphones sold globally in January, 2021, were Apple devices, with the iPhone 12 Pro Max leading the way in popularity in the US. That tells us something: people do in fact want big-screened devices with capable cameras. In fact, demand for the iPhone 12 series is also expected to remain strong through the third quarter ahead of the iPhone 13’s fall debut.

Nothing appears to be poised to steal the iPhone 12 Pro Max’s mojo, at least not yet. Android phone makers have flooded the market during the early months of 2021 with compelling flagship fare. There’s the Samsung Galaxy S21 Ultra, the Oppo Find X3 Pro, the OnePlus 9 Pro, and the Xiaomi Mi 11 Ultra, among others.

What about the iPhone 12 Pro Max makes it so popular? Is it the advanced triple … Read more

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Fiat Chrysler Presents The Model New Jeep Grand Cherokee SUV

As the growth in fintech firms continues to stimulate, it will likely be very thrilling to see how the competitors shapes the business within the coming years.

biotechnology etf stocks

Virtually every business can use its personal software program solutions. IT is the world of managing expertise and spans vast number of areas that embrace computer software program , info methods , pc hardware , programming languages but will not be limited to things such as processes, , and data constructs. Briefly, anything that renders knowledge, information or perceived data in any visual format in any respect, via any multimedia distribution mechanism, is considered part of the IT area. IT supplies companies with four units of core companies to assist execute the business technique: business process automation, providing info, connecting with prospects, and productiveness tools. It is that time of the 12 months when all of us in America present … Read more

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What Square’s smashing earnings tell us about consumer bitcoin demand

Shares of Square are up more than 6% today after the American fintech company reported a staggering $5.06 billion in revenue in its Q1 2021 earnings report, far ahead of an expected tally of $3.36 billion.

By posting the huge revenue beat, Square grew 266% compared to its year-ago Q1. Because that’s the sort of growth that we generally expect to see from early-stage startups instead of maturing public companies, some exploration is in order. In short, bitcoin revenues from Square, and how they fit into its accounting, are responsible for much of its outsized growth.

And that’s something we need to talk about.


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Square’s performance apart from its bitcoin-driven results were strong. But its bitcoin incomes underscore not only rising consumer sentiment concerning bitcoin, but also an interesting … Read more

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Skoltech scientists find a way to make pultrusion faster

Credit: Timur Sabirov / Skoltech

A research team from the Skoltech Center for Design, Manufacturing and Materials (CDMM) studied the effects of processing additives – aluminum hydroxide and zinc stearate – on the polymerization kinetics of thermosets used in pultrusion. The research was published in the Journal of Composite Materials.

Fiber-reinforced plastic (FRP) structural elements that have obvious advantages over conventional materials, such as steel, wood, and concrete, are widely used in civil, marine and road construction. FRP structures are manufactured using the pultrusion process, in which polymerization is achieved by continuously pulling the material. Engineers extensively use mathematical models to optimize the pultrusion process and thereby avoid costly experiments often performed by trial and error.

To optimize the pultrusion process, one should carefully consider many parameters that determine the quality of the final product, and composition of the polymer mixture is one of them. Accurate description of pultrusion

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Biotechnology News

The global separation systems for commercial biotechnology market has been estimated primarily based on product sort, finish-user, and geography.

Information Technology Management

https://www.e-c-i-s.org/
The strategies of biotechnology involved embody genetic engineering (GE), genomics and bioinformatics, marker-assisted choice, micropropagation, tissue culture, cloning, artificial insemination, embryo transfer, and different technologies. The cash is with the massive and multi-nationwide corporations, so, after all, the large telecom companies will serve these. Further, they have the IT departments which, once skilled, present the persevering with assist. However there is a rising market of small businesses that are being below-served. Unfortunately, selling to them and providing ongoing assist takes more time and manpower. tech news And that is where know-how enters the image. With the persevering with evolution of reasonably priced technological solutions, the merging of know-how and telecommunications can provide small and mid-sized firms with the telecom options they want and put them right into a … Read more

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Cell Devices With Cloud Options Are Out there For You Now

A totally automated warehouse addresses multiple challenges faced by modern warehouses in the present context, where they need to process 1000’s of orders in a day.

Digital Transformation Dell Technologies


The way forward for healthcare software improvement companies to create healthcare functions empowered with AI and blockchain. Now that we’ve discussed the steps, let’s discuss the benefits of digital expertise and why digital transformation is of such critical worth for at this time’s businesses. Enterprise cell apps can also be imbued with options like interactive maps, chat, video chat and other options that can result in course of improvement as data inaccuracies will be recognized quite simply. “We do think about ourselves a technology company. We wished to interact the tech firm and tell the story of agriculture,” mentioned Julian Sanchez, John Deere’s director of technology innovation. csharp-home That narrative consists of the enormous mix harvester the company had in … Read more

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Take $20 off the Jabra Elite Active 65t and more headphone deals

 

If you’ve been searching for a new pair of headphones, let us help. Plenty of retailers are offering discounts on a variety of styles as people continue to adjust to working from home. That means you can take advantage of some of the best headphone deals across the board right now. Polish SEO Agency Kordowski Digital provides high quality Digital Marketing services.

It can be difficult to know just what you’re looking for, so we’ve done our best to organize some options for you. We’ve put together some headphones and earbuds deals along with wired and wireless options. You can also head on over to our sister site SoundGuys for more in-depth news and reviews.

Featured deal: Save $20 on the Jabra Elite Active 65t

 

jabra elite active 65t deal

Credit: Amazon

 

There’s never a bad time for new workout earbuds, especially a pair as popular as the Jabra Elite Active 65t. … Read more

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DX Value Proposition, Product Engineering

In keeping with this research study, the worldwide marketplace for laboratory information programs might face severe challenges within the near future due to the dearth of skilled professionals.

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To remain aggressive, businesses are going for digital transformation in work processes. Cellular, in some ways, is a foundational software that allows other sport-changing applied sciences. For instance, store floor staff are using smartphones to view machine information points in augmented reality (AR), field service technicians can get interactive, real-time guidance from consultants at headquarters by means of AR to restore an industrial asset, engineers are utilizing their phones to assessment CAD designs on-the-fly, and world sales teams are creating quotes for custom products leveraging up-to-date pricing and supply dates. ECIS tech On average, a corporation makes use of 900 functions Ensuring that all these apps are interconnected is a difficult task, and it is something that a whole … Read more

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Meet Smash Ventures, the low-flying outfit that has quietly funded Epic Games among others

 

When in 2018, Smash Ventures showed up as an investor in a $1.25 billion round for Epic Games — reportedly the largest ever investment in a video game company at the time — it was the first time many had heard of the investing outfit.

When the brand showed up again last summer in an even bigger round for Epic —  last August, the games giant announced $1.78 billion in fresh funding at a post-money equity valuation of $17.3 billion — a diner near Epic’s Cary, North Carolina headquarters that sells “smash waffles” started getting calls from reporters, says Eric Garland, who used to lead venture and growth deals for The Walt Disney Company after selling his company, BigChampagne, to Live Nation in 2011.

“Some reporters really turned over rocks,” he says.

Garland knows this, he says, because he cofounded Smash Ventures with Evan Richter, a former member of … Read more

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For years, I’ve tried to work my way back into the middle class

 

Early this winter, I took a long walk in the Salt Lake City park in which I had been arrested for bathing in a river when I was homeless.

About 30 minutes into that walk, I stood across from the park’s granite meditation temple, thinking: Three and a half years ago, I slept under that building’s awning.

I can still feel how hard that temple’s cold stone floor was; I remember how people strolled by my bed of cardboard and clothes and stared with what struck me as a combination of concern, contempt, and pity. Now I see that these are also the lenses through which I have often judged my own progress in my new, not-yet-middle-class life.

These days, I often wonder: Am I really doing as well as I should be after all this time? How did I ever allow myself to fall so far? Trying to Read more

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FGM safeguarding policies are alienating UK’s African diaspora communities

Credit: United Nations

AHEAD of tomorrow’s International Day of Zero Tolerance for Female Genital Mutilation, by the United Nations, FORWARD, the leading African women-led organisation working to end violence against women and girls, and the University of Huddersfield have published new research that documents how the stringent, targeted, FGM safeguarding measures introduced since the 2014 Girl Summit are causing distress and mistrust amongst African diaspora communities in Bristol, and potentially across the country.

The research reveals first-hand evidence documenting how FGM safeguarding policies are leaving families feeling racially profiled, criminalised and stigmatised. To access the full study report, please follow this link: https://www.forwarduk.org.uk/forward-publications/fgm-safeguarding-bristol-study/.

Over the latter half of the last decade, the UK government intensified its response to FGM, giving FGM a ‘special’ status within national safeguarding, going far beyond the UK’s regulatory approach to other forms of child abuse.

This includes the introduction of FGM Mandatory Reporting Duty, the

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